Cisplatin pulmonary fibrosis

Author: krew

August undefined, 2024

WebFeb 22, 2016 · In patients treated for disseminated testicular cancer with bleomycin, etoposide, and cisplatin (BEP), the risk of acute bleomycin-induced changes is ≤ 6.8%, with a 0% to 1% risk of death. 1 - 4 Serious long-term toxicity has been indicated with an increased risk of late mortality caused by pulmonary diseases. 5 These findings were … WebFeb 24, 2024 · Certain chemotherapy medications, such as cisplatin, can cause damage to the kidneys and bladder. This can result in a decreased ability of your kidneys to filter your blood. Damage to the bladder can also occur and may be temporary or permanent. Symptoms of bladder irritation may include pain or urgency with urination, or blood in …

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WebMar 2, 2016 · Cisplatin is known to intercalate DNA by the formation of cross-links. The damage done by cisplatin leads to inhibition of DNA replication followed by apoptosis or … WebOct 15, 2024 · Cisplatin forms intrastrand crosslinks in DNA, which disturbs DNA replication and causes DNA damage, eventually inducing necrosis or apoptosis. Cisplatin-based chemotherapy is widely used to... cynthia cynor wirth

Germ cell cancer in pregnancy- successfully treated with …

WebSep 8, 2024 · Interstitial lung disease (ILD) is a disease with progressive deterioration of respiratory function ( 1 ). ILD is an independent risk factor for lung cancer (LC). Among patients diagnosed with lung cancer, 5.8–15.2% of patients have ILD ( 2, 3 ). WebPulmonary fibrosis is a group of serious lung diseases that affect the respiratory system. Pulmonary fibrosis scars and thickens lung tissue. It impacts the connecting tissue in the lung and the alveoli (air sacs inside the lungs). The … WebMar 2, 2016 · However, co-culture in vitro experiments and co-implantation in vivo experiments showed that the combination of low doses of cisplatin (10 μM) and low doses of pirfenidone (0.5 mg/mL), in both CAFs and tumors, lead to increased cell death and decreased tumor progression, respectively. billy sio

Complete regression of pulmonary squamous carcinoma in IPF …

Commonly reported side effectsof cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of adverse effects. Applies to cisplatin: intravenous powder for solution, intravenous solution. See more Along with its needed effects, cisplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do … See more Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some side effects may not be reported. You … See more Some side effects of cisplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your … See more WebThe anticancer drug cisplatin induces cell death by apoptosis. Apoptosis is dependent on cellular loss of potassium ions (K+). We have recently shown that the antifungal drug amphotericin B (enhancin cynthia cypert actressWebMar 20, 2024 · Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with an undefined etiology and poor prognosis. The prevalence of lung cancer is much … cynthia curtis st.charles mo

"WebThe clinical and histopathological data as well as the lack of an infectious cause indicate that pulmonary fibrosis was induced by oxaliplatin and 5-FU/folinic acid. Conclusion: This case demonstrates that treatment with oxaliplatin and 5-FU/folinic acid can cause acute pulmonary fibrosis. " - Cisplatin pulmonary fibrosis

Cisplatin pulmonary fibrosis

Pulmonary Function in Patients With Germ Cell Cancer Treated …

WebPulmonary fibrosis (PF) is part of a larger group of more than 200 interstitial lung diseases (also known as ILDs) that are characterized by inflammation and/or scarring in the lung. In ILDs, the injury and damage …

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WebApr 10, 2024 · In addition, pulmonary toxicity is a common but significant side effect of bleomycin which can lead to pulmonary fibrosis and increased mortality (Brandt and Gerriets, 2024). ... paclitaxel in combination with cisplatin has been used to treat ovarian mucinous adenocarcinoma during pregnancy with no negative outcomes to the child, ... WebMar 6, 2024 · Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. This thickened, stiff tissue makes it more difficult for your lungs to work properly. As pulmonary fibrosis …

WebOct 25, 2024 · The most serious complications of bleomycin are pneumonitis (bleomycin-induced pneumonitis–BIP) and pulmonary fibrosis, but other lung pathology includes … WebSome of the more common medication types that are known to carry the risk of pulmonary fibrosis include certain: antibiotics, particularly nitrofurantoin immunosuppressant drugs, such as methotrexate drugs for heart conditions, particularly amiodarone cancer chemotherapy drugs biological agents used to treat cancer or immune disorders.

WebBackground: Gemcitabine is the only approved cytotoxic agent for the treatment of pancreatic cancer by the Food and Drug Administration. In addition, gemcitabine is also commonly used for the management of breast, ovarian, and non-small cell lung cancer. Myelosuppression is the most common toxicity of gemcitabine therapy. WebAlthough cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity 掌桥科研一站式科研服务平台

WebApr 15, 2024 · Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with unclear pathogenesis. IPF is considered as a risk factor for lung cancer. …

WebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, billy singing fishWebMar 8, 2024 · Cisplatin is implicated in promoting lung fibrosis, which indicates that IPF fibroblasts cultured on a collagen matrix are resistant to cisplatin-induced cell death. To test this, we first treated non-IPF and IPF fibroblasts (n = 8 each) with various doses of cisplatin, and their viability was measured. cynthia cynthiaWebAbstract. Idiopathic pulmonary fibrosis (IPF) is a deadly and progressive fibrotic lung disease, but the precise etiology remains elusive. IPF is characterized by the presence … cynthia cynthia steffe tweed jacketWebMar 12, 2024 · Interstitial inflammation, fibrosis, structural pulmonary damage, and other severe complications have also been reported during cisplatin chemotherapy [ 5 ]. These adverse effects of cisplatin-induced … billy sings a song 2WebAug 7, 2024 · Its potent anti-inflammatory and anti-fibrotic effects were demonstrated in animal models of lung fibrosis including bleomycin-induced lung injury and fibrosis. Oku et al. showed that both prophylactic and therapeutic administration of pirfenidone attenuated lung fibrosis induced by intravenous bleomycin in mice [ 5 ]. billy sings a song lyricsWebChemotherapy has dramatically improved the prognosis, and bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy appears to be the most effective combination regimen. A 23-year-old woman was admitted to our hospital with worsening abdominal distention and a lower abdominal mass. billy siounisWebMar 20, 2024 · Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with an undefined etiology and poor prognosis. The prevalence of lung cancer is much higher in IPF patients than in the general population, and lung cancer significantly worsens the prognosis of IPF [ 1 ]. billy sings the blues