Cisplatin induced nephrotoxicity mechanism
WebOct 5, 2014 · Cisplatin induced toxicities, especially nephrotoxicity, seem to be related to a decrease in the intracellular concentrations of GSH and protein bound SH-groups. … WebMar 9, 2024 · The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to aggravate AKI induced by cisplatin.
Cisplatin induced nephrotoxicity mechanism
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Webrotection against gentamicin-induced nephrotoxicity in rats (Sandhya et al. 1995). Interestingly, the dose of an antioxi-dant lipoic acid (0.12–0.48 mmole/kg) required to protect cisplatin-induced nephrotoxicity (16 mg/kg) in rats was three to twelve times less than that of a chelating agent 4- WebMay 12, 2024 · The key of anti-tumor effect of cisplatin is damage to DNA of tumor, which also lead to renal injury. 2,3 Some reports link cisplatin poisoning with organelle dysfunction, such as endoplasmic reticulum, cytoskeleton, and mitochondria, both in vivo and in vitro. Apoptosis and necrosis of renal tubular cells play a major role in cisplatin …
WebThe proteinuria associated with cisplatin nephrotoxicity is attributed to a tubular defect. 32 Hemolytic uremic syndrome has also been described, especially when cisplatin is combined with bleomycin. 33 Sequential … WebSep 1, 2024 · The mechanism of cisplatin-induced nephrotoxicity (CIN) has long been investigated in order to develop preventive/therapeutic drugs. Ferroptosis is a newly …
WebSep 27, 2024 · Cisplatin induces cancer cell death by binding to the N7 reactive center of purine residues and causes irreversible DNA damage in cancer cells during division ( Dasari and Tchounwou, 2014 ), thus blocking cell division and promoting apoptosis. WebDec 16, 2024 · In this study, Cisplatin NanoComposite (Cis NC) was formulated successfully from irradiated chitosan coated Cisplatin and MgO nanoparticles …
WebJan 3, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and …
WebMay 1, 2008 · Overview of the pathophysiological events in cisplatin nephrotoxicity. Cisplatin enters renal cells by passive and/or facilitated mechanisms. Exposure of … thomson first choice holidaysWebCisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years … uline book cartWebThe manufacturer recommends that an alerting mechanism be instituted to verify any order for cisplatin >100 mg/m. 2. per course every 3-4 weeks. ... induced diuresis to effectively decrease cisplatin-induced nephrotoxicity. 7. Refer to protocol by which patient is being treated. Numerous hydration regimens exist. thomson first callWebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of … uline bluetooth padlockWebFeb 2, 2024 · Some studies have found that vinorelbine protects against cisplatin-induced acute kidney injury (AKI) by activating Nrf2/HO-1 signaling pathway and hindering TLR4-IFN-γ-CD44 cell inflammatory cascade when investigating the molecular mechanism of renal protection against nephrotoxicity (El-Sayed et al., 2024). thomson fkh509WebOct 11, 2024 · Experimentally induced sepsis (via LPS) also potentiates the degree of cisplatin-induced hearing loss in mice (Oh et al., 2011). LPS-induced inflammation in … uline boat shrink wrapWebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … uline bluetooth speaker